Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | TDO2 | P48775 | 1/20 | 0.59 |
| ▸ | CTSK | P43235 | 7/20 | 0.58 |
| ▸ | CTSB | P07858 | 4/20 | 0.58 |
| ▸ | CTSL | P07711 | 3/20 | 0.58 |
| ▸ | CTSS | P25774 | 2/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.53 |
| ▸ | ITGAV | P06756 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1440950 | 1.00 | IDO1 (0.59) | IDO1TDO2CTSKCTSBCTSL | |
| SCHEMBL1440952 | 1.00 | IDO1 (0.59) | IDO1TDO2CTSKCTSBCTSL | |
| SCHEMBL25282429 | 0.95 | CTSK (0.65) | IDO1TDO2CTSKCTSBCTSL | |
| SCHEMBL15649121 | 0.95 | CTSK (0.62) | IDO1TDO2CTSKCTSBCTSL | |
| SCHEMBL25282430 | 0.95 | CTSK (0.65) | IDO1TDO2CTSKCTSBCTSL | |
| SCHEMBL22122405 | 0.95 | CTSK (0.62) | IDO1TDO2CTSKCTSBCTSL | |
| SCHEMBL28546631 | 0.93 | CTSK (0.67) | IDO1TDO2CTSKCTSBCTSL | |
| SCHEMBL4800376 | 0.93 | CTSK (0.67) | IDO1TDO2CTSKCTSBCTSL | |
| SCHEMBL4622697 | 0.93 | CTSK (0.67) | IDO1TDO2CTSKCTSBCTSL | |
| SCHEMBL7469120 | 0.89 | CTSK (0.59) | IDO1CTSKCTSBCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629627-B1 | Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2004-05-06 | — | — | EP | disclosed |
| US-5627278-A | MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION | BRISTOL-MYERS SQUIBB CO. (US) | 1997-05-06 | — | — | US | disclosed |
| US-5508272-A | SELECTIVE ACE INHIBITORS, HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-16 | — | — | US | disclosed |
| EP-0629627-A2 | Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-21 | — | — | EP | disclosed |