Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 8/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.60 |
| ▸ | CDK2 | P24941 | 7/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.60 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.49 |
| ▸ | POLA1 | P09884 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 4/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1146063 | 0.94 | CDK1 (0.61) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL28091022 | 0.83 | PDPK1 (0.56) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL2060155 | 0.82 | PDPK1 (0.51) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL27818523 | 0.82 | PDPK1 (0.54) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL8207461 | 0.80 | CDK1 (0.56) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL30610405 | 0.78 | CDK1 (0.53) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL6897931 | 0.77 | CDK1 (0.46) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL453220 | 0.77 | PDPK1 (0.59) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL29387231 | 0.77 | PDPK1 (0.59) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL28299226 | 0.77 | POLA1 (0.53) | CDK1CCNB1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604409-B1 | OLIGONUCLEOTIDE ANALOGS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION | ISIS PHARMACEUTICALS INC (US) | 2004-07-14 | — | — | EP | disclosed |
| EP-1418179-A2 | Compositions and methods for detecting and modulating rna activity and gene expression | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6262241-B1 | ANTISENSE COMPOUNDS WHICH CLEAVE PHOSPHORODIESTER BONDS AND IMPROVE PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES OF OLIGONUCLEOTIDES, USEFUL IN DIAGNOSING DISEASES | ISIS PHARMACEUTICALS, INC. | 2001-07-17 | — | — | US | disclosed |
| EP-0604409-A4 | COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION. | ISIS PHARMACEUTICALS INC (US) | 1996-06-12 | — | — | EP | disclosed |
| EP-0604409-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 1994-07-06 | — | — | EP | disclosed |
| WO-1991010671-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 1991-07-25 | — | — | WO | disclosed |