SCHEMBL6898288

SCHEMBL6898288

CN1c2ccccc2CC1COc1ccc(CC2SC(=O)NC2=O)cc1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PPARG P37231 10/20 0.56
FFAR1 O14842 10/20 0.56
HRH3 Q9Y5N1 1/20 0.53
MEN1 O00255 1/20 0.51
ALDH1A1 P00352 1/20 0.51
TP53 P04637 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
MAPT P10636 1/20 0.51
HPGD P15428 1/20 0.51
ALOX15 P16050 1/20 0.51
TSHR P16473 1/20 0.51
KMT2A Q03164 1/20 0.51
HSD17B10 Q99714 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
PPARA Q07869 3/20 0.49
MPC2 O95563 1/20 0.47
CYP2C8 P10632 1/20 0.47
CYP2C9 P11712 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL291316 0.79 HRH3 (0.59) PPARGFFAR1HRH3MEN1ALDH1A1
SCHEMBL30385807 0.79 HRH3 (0.59) PPARGFFAR1HRH3MEN1ALDH1A1
SCHEMBL9429683 0.78 PPARG (0.56) PPARGFFAR1HRH3MEN1ALDH1A1
SCHEMBL6601560 0.78 PPARG (0.52) PPARGFFAR1HRH3MEN1ALDH1A1
SCHEMBL6601704 0.77 PPARG (0.51) PPARGFFAR1HRH3MEN1ALDH1A1
SCHEMBL7835306 0.76 FFAR1 (0.55) PPARGFFAR1HRH3MEN1ALDH1A1
SCHEMBL8128813 0.75 PPARG (0.63) PPARGFFAR1HRH3MEN1ALDH1A1
SCHEMBL6602049 0.75 FFAR1 (0.49) PPARGFFAR1HRH3MEN1ALDH1A1
SCHEMBL6602967 0.75 FFAR1 (0.49) PPARGFFAR1HRH3MEN1ALDH1A1
SCHEMBL8460445 0.75 FFAR1 (0.57) PPARGFFAR1HRH3MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0919232-B1 Composition for use in the treatment and prevention of hyperuricemia SANKYO CO (JP) 2004-10-06 EP claimed
US-6353009-B1 TREATMENT OF GOUT WITH ANTIINFLAMMATORY AGENTS SANKYO COMPANY, LIMITED (JP) 2002-03-05 US claimed
EP-0796618-B1 Treatment and prophylaxis of pancreatitis SANKYO CO (JP) 2002-01-30 EP claimed
US-6150371-A WITH THE EXCEPTION OF TYPE I DIABETES; INHIBITS INVASION OF ORGAN TISSUE BY CYTOTOXIC LYMPHOCYTES; ADMINISTERING TO A MAMMAL AN ANTIAUTOIMMUNE DISEASE AGENT BEING AN INSULIN RESISTANCE REDUCING AGENT, ANTIDIABETIC, E.G., TROGLITAZONE SANKYO COMPANY, LIMITED (JP) 2000-11-21 US claimed
EP-0919232-A1 Composition for use in the treatment and prevention of hyperuricemia Sankyo Company Limited (JP) 1999-06-02 EP claimed
US-5834501-A TREATING DIABETES OR HYPERLIPEMIA SANKYO COMPANY, LIMITED (JP) 1998-11-10 US claimed
EP-0796618-A1 Treatment and prophylaxis of pancreatitis SANKYO COMPANY LIMITED (JP) 1997-09-24 EP claimed
EP-0919232-B1 Composition for use in the treatment and prevention of hyperuricemia SANKYO CO (JP) 2004-10-06 EP disclosed
US-6353009-B1 TREATMENT OF GOUT WITH ANTIINFLAMMATORY AGENTS SANKYO COMPANY, LIMITED (JP) 2002-03-05 US disclosed
EP-0796618-B1 Treatment and prophylaxis of pancreatitis SANKYO CO (JP) 2002-01-30 EP disclosed
EP-0676398-B1 Heterocyclic compounds having anti-diabetic activity, their preparation and their use SANKYO CO (JP) 2001-10-24 EP disclosed
US-6150371-A WITH THE EXCEPTION OF TYPE I DIABETES; INHIBITS INVASION OF ORGAN TISSUE BY CYTOTOXIC LYMPHOCYTES; ADMINISTERING TO A MAMMAL AN ANTIAUTOIMMUNE DISEASE AGENT BEING AN INSULIN RESISTANCE REDUCING AGENT, ANTIDIABETIC, E.G., TROGLITAZONE SANKYO COMPANY, LIMITED (JP) 2000-11-21 US disclosed
US-6117893-A Heterocyclic compounds having anti-diabetic activity and their use SANKYO COMPANY, LIMITED (JP) 2000-09-12 US disclosed
EP-0953355-A1 REMEDY FOR AUTOIMMUNE DISEASES Sankyo Company, Limited (JP) 1999-11-03 EP disclosed
US-5977365-A HYPOGLYCEMIC AGENTS SANKYO COMPANY, LIMITED (JP) 1999-11-02 US disclosed
US-5968960-A ANTIISCHEMIC AGENTS AND HYPOTENSIVE AGENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-10-19 US disclosed
EP-0919232-A1 Composition for use in the treatment and prevention of hyperuricemia Sankyo Company Limited (JP) 1999-06-02 EP disclosed
EP-0796618-A1 Treatment and prophylaxis of pancreatitis SANKYO COMPANY LIMITED (JP) 1997-09-24 EP disclosed
US-5624935-A ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS SANKYO COMPANY, LIMITED 1997-04-29 US disclosed
EP-0676398-A2 Heterocyclic compounds having anti-diabetic activity, their preparation and their use SANKYO COMPANY LIMITED (JP) 1995-10-11 EP disclosed