SCHEMBL291316

SCHEMBL291316

O=C1NC(=O)C(Cc2ccc(OCCN3CCc4ccccc43)cc2)S1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.59
FFAR1 O14842 11/20 0.57
PPARG P37231 9/20 0.57
PPARA Q07869 2/20 0.50
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
TP53 P04637 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
MAPT P10636 1/20 0.49
HPGD P15428 1/20 0.49
ALOX15 P16050 1/20 0.49
TSHR P16473 1/20 0.49
KMT2A Q03164 1/20 0.49
HSD17B10 Q99714 1/20 0.49
TDP1 Q9NUW8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30385807 1.00 HRH3 (0.59) HRH3FFAR1PPARGPPARAMEN1
SCHEMBL9123993 0.88 HRH3 (0.57) HRH3FFAR1PPARGPPARAMEN1
SCHEMBL8133025 0.84 HRH3 (0.57) HRH3FFAR1PPARGPPARAMEN1
SCHEMBL8126354 0.83 HRH3 (0.56) HRH3FFAR1PPARGPPARAMEN1
SCHEMBL6505839 0.82 PPARG (0.46) HRH3FFAR1PPARGPPARAMEN1
SCHEMBL8460445 0.82 FFAR1 (0.57) HRH3FFAR1PPARGPPARAMEN1
SCHEMBL8796744 0.79 PPARG (0.55) HRH3FFAR1PPARGPPARAMEN1
SCHEMBL6898288 0.79 PPARG (0.56) HRH3FFAR1PPARGPPARAMEN1
SCHEMBL7834886 0.78 MEN1 (0.37) HRH3FFAR1PPARGMEN1ALDH1A1
SCHEMBL8128813 0.78 PPARG (0.63) HRH3FFAR1PPARGPPARAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 280 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12209144-B2 Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders NOVARTIS AG (CH) 2025-01-28 US disclosed
US-20240036046-A1 CANCER EXAMINATION METHOD AND CANCER TREATMENT AGENT IMAMITSUKAI MEDICAL CORPORATION (JP) 2024-02-01 US disclosed
US-11813306-B2 Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders NOVARTIS AG (CH) 2023-11-14 US disclosed
EP-4252773-A1 CANCER EXAMINATION METHOD AND CANCER TREATMENT AGENT Imamitsukai Medical Corporation (JP) 2023-10-04 EP disclosed
US-20230089867-A1 CYCLIC PENTAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDER NOVARTIS AG (CH) 2023-03-23 US disclosed
US-11426375-B2 Substituted bisphenyl butanoic ester derivatives as NEP inhibitors NOVARTIS AG (CH) 2022-08-30 US disclosed
US-20220024981-A1 CYCLIC PEPTIDES AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS NOVARTIS AG (CH) 2022-01-27 US disclosed
EP-3887365-A1 CYCLIC TETRAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS Novartis AG (CH) 2021-10-06 EP disclosed
EP-3887363-A1 CYCLIC PENTAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDER Novartis AG (CH) 2021-10-06 EP disclosed
EP-3887388-A1 CYCLIC PEPTIDES AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS Novartis AG (CH) 2021-10-06 EP disclosed
US-20010016586-A1 Use of organic compounds NOVARTIS AG (CH) 2001-08-23 US disclosed
WO-2001052825-A2 COMBINATIONS COMPRISING DIPEPTIDYLPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS NOVARTIS AG (CH) 2001-07-26 WO disclosed
WO-2001047514-A1 USE OF HYPOGLYCEMIC AGENT FOR TREATING IMPAIRED GLUCOSE METABOLISM NOVARTIS AG (CH) 2001-07-05 WO disclosed
WO-2001026639-A2 PHARMACEUTICAL COMPOSITION OF ATEGLINIDE AND ANOTHER ANTIDIABETICAGENT NOVARTIS AG (CH) 2001-04-19 WO disclosed
WO-2001021159-A2 PHARMACEUTICAL COMPOSITION OF NATEGLINIDE AND ANOTHER ANTIDIABETCAGENT NOVARTIS AG (CH) 2001-03-29 WO disclosed
US-6117893-A Heterocyclic compounds having anti-diabetic activity and their use SANKYO COMPANY, LIMITED (JP) 2000-09-12 US disclosed
EP-1022274-A1 Oxazolidinedione and Thiazolidinedione derivatves, their preparation and their use Sankyo Company Limited (JP) 2000-07-26 EP disclosed
US-5977365-A HYPOGLYCEMIC AGENTS SANKYO COMPANY, LIMITED (JP) 1999-11-02 US disclosed
US-5624935-A ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS SANKYO COMPANY, LIMITED 1997-04-29 US disclosed
EP-0676398-A2 Heterocyclic compounds having anti-diabetic activity, their preparation and their use SANKYO COMPANY LIMITED (JP) 1995-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11813306-B2 Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders PCSK9, PCSK7, PCSK6 HRH3 2147/4885FFAR1 256/4885PPARG 3245/4885
US-20220024981-A1 CYCLIC PEPTIDES AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS PCSK9, PCSK7, PCSK6 HRH3 1895/4885FFAR1 1045/4885PPARG 3421/4885
US-11426375-B2 Substituted bisphenyl butanoic ester derivatives as NEP inhibitors MME, REN, ECE1 HRH3 915/4885FFAR1 654/4885PPARG 3634/4885
US-20230089867-A1 CYCLIC PENTAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDER PCSK9, PCSK7, PCSK6 HRH3 1090/4885FFAR1 144/4885PPARG 2984/4885
US-12209144-B2 Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders PCSK9, PCSK7, PCSK6 HRH3 1895/4885FFAR1 1045/4885PPARG 3421/4885
US-20010016586-A1 Use of organic compounds APOL1, APOB, SLC5A2 HRH3 4158/4885FFAR1 1139/4885PPARG 358/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.