Benzonitrile

Benzonitrile

SCHEMBL6899298

N#Cc1ccccc1.N#Cc1ccccc1.O=S(=O)([O-])OS(=O)(=O)[O-].[Pt+2]

nearest known ligand 0.56

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.56
MAPT P10636 1/20 0.43
ACLY P53396 1/20 0.40
CA1 P00915 3/20 0.40
CA2 P00918 3/20 0.40
CA9 Q16790 3/20 0.40
CA12 O43570 2/20 0.40
CYP19A1 P11511 1/20 0.40
MAOB P27338 2/20 0.39
MAOA P21397 1/20 0.39
AR P10275 1/20 0.39
CTSG P08311 1/20 0.38
CMA1 P23946 1/20 0.38
PGR P06401 2/20 0.38
NR3C1 P04150 1/20 0.38
STAT3 P40763 1/20 0.38
KEAP1 Q14145 1/20 0.37
NFE2L2 Q16236 1/20 0.37
EEF2K O00418 1/20 0.37
THRB P10828 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzonitrile SCHEMBL6899297 0.83 TSHR (0.67) TSHRMAPTACLYCA1CA2
Benzonitrile SCHEMBL4710240 0.83 TSHR (0.67) TSHRMAPTCA1CA2CA9
Benzonitrile SCHEMBL7635217 0.78 TSHR (0.58) TSHRMAPTCA1CA2CA9
Benzonitrile SCHEMBL27923901 0.76 TSHR (0.70) TSHRMAPTCA1CA2CA9
Benzonitrile SCHEMBL28806619 0.76 TSHR (0.70) TSHRMAPTCA1CA2CA9
Benzonitrile SCHEMBL65862 0.76 TSHR (0.70) TSHRMAPTCA1CA2CA9
Benzonitrile SCHEMBL7635221 0.76 TSHR (0.70) TSHRMAPTCA1CA2CA9
Benzonitrile SCHEMBL12469615 0.76 TSHR (0.70) TSHRMAPTCA1CA2CA9
Benzonitrile SCHEMBL29059725 0.75 TSHR (0.88) TSHRMAPTCA1CA2CA9
Benzonitrile SCHEMBL9438699 0.75 TSHR (0.88) TSHRMAPTCA2CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1222157-B1 PROCESS FOR THE CARBONYLATION OF AN ACETYLENICALLY UNSATURATED COMPOUND SHELL INT RESEARCH (NL) 2004-04-28 EP disclosed
EP-0877728-B1 PROCESS FOR THE CARBONYLATION OF ACETYLENICALLY UNSATURATED COMPOUNDS SHELL INT RESEARCH (NL) 2000-04-05 EP disclosed
US-5952522-A CATALYZING THE REACTION WITH CARBON MONOXIDE AND A CO-REACTANT IN THE PRESENCE OF A CATALYST SYSTEM COMPRISING A SOURCE OF PLATINUM, A BIDENTATE LIGAND AND A SOURCE OF ANIONS SHELL OIL COMPANY (US) 1999-09-14 US disclosed
EP-0877728-A1 PROCESS FOR THE CARBONYLATION OF ACETYLENICALLY UNSATURATED COMPOUNDS SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1998-11-18 EP disclosed
WO-1997020803-A1 PROCESS FOR THE CARBONYLATION OF ACETYLENICALLY UNSATURATED COMPOUNDS SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1997-06-12 WO disclosed