Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 3/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6899312 | 0.80 | PSMB8 (0.39) | PSMB8PSMB5ADRA2AADRA2BADRA2C | |
| SCHEMBL6897746 | 0.73 | PSMB8 (0.36) | PSMB8PSMB5ADRA2AADRA2BADRA2C | |
| SCHEMBL28731734 | 0.72 | TAAR1 (0.41) | PSMB8PSMB5ADRA2AADRA2BADRA2C | |
| SCHEMBL13117923 | 0.72 | LTB4R (0.46) | — | |
| SCHEMBL25675782 | 0.72 | LTB4R (0.46) | — | |
| SCHEMBL23505795 | 0.72 | LTB4R (0.46) | — | |
| SCHEMBL25675810 | 0.72 | LTB4R (0.46) | — | |
| SCHEMBL13881209 | 0.72 | LTB4R (0.46) | — | |
| SCHEMBL20480237 | 0.71 | PSMB8 (0.47) | PSMB8PSMB5ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL29121801 | 0.70 | HTR2A (0.41) | PSMB8PSMB5ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509950-B1 | 5-Amino-4-hydroxypentoyl amides | JANSSEN R & D IRELAND (IE) | 2015-02-25 | — | — | EP | disclosed |
| WO-2011070131-A1 | 5-AMINO- 4-HYDROXYPENTOYL AMIDES | TIBOTEC PHARMACEUTICALS (IE) | 2011-06-16 | — | — | WO | disclosed |