Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clofibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 6/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | CNR1 | P21554 | 4/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | FBP1 | P09467 | 7/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clofibrate SCHEMBL8015285 | 0.91 | PPARA (0.54) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL4422408 | 0.86 | PPARA (0.68) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL4423002 | 0.83 | PPARA (0.59) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| Clofibrate SCHEMBL28086141 | 0.81 | PPARA (0.94) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| Clofibrate SCHEMBL2356 | 0.81 | PPARA (1.00) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| Clofibrate SCHEMBL3953607 | 0.81 | PPARA (1.00) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| Clofibrate SCHEMBL11187010 | 0.79 | PPARA (0.97) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| Clofibrate SCHEMBL11180679 | 0.79 | PPARA (0.97) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| Clofibrate SCHEMBL3345 | 0.79 | PPARA (0.97) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| Clofibrate SCHEMBL29262880 | 0.79 | PPARA (0.97) | PPARAABCB11CYP1A2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019059-A4 | USE OF FXR, PPARalpha AND LXRalpha ACTIVATORS TO RESTORE BARRIER FUNCTION, PROMOTE EPIDERMAL DIFFERENTIATION AND INHIBIT PROLIFERATION | UNIV CALIFORNIA (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-1019059-A1 | USE OF FXR, PPARalpha AND LXRalpha ACTIVATORS TO RESTORE BARRIER FUNCTION, PROMOTE EPIDERMAL DIFFERENTIATION AND INHIBIT PROLIFERATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998032444-A1 | USE OF FXR, PPARα AND LXRα ACTIVATORS TO RESTORE BARRIER FUNCTION, PROMOTE EPIDERMAL DIFFERENTIATION AND INHIBIT PROLIFERATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-07-30 | — | — | WO | disclosed |