Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | HRAS | P01112 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14535121 | 0.85 | TOP1 (0.45) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL8889890 | 0.84 | TDP1 (0.41) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL24063140 | 0.83 | TOP1 (0.44) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL14002824 | 0.81 | HRAS (0.45) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL6576431 | 0.81 | AR (0.39) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL20581230 | 0.80 | HRAS (0.42) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL5748171 | 0.80 | HRAS (0.42) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL5748174 | 0.80 | TOP1 (0.62) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL14002822 | 0.80 | TOP1 (0.62) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL14509989 | 0.79 | MEN1 (0.49) | KDM4EP2RY12TP53SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430028-A2 | AROMATIC AND HETEROAROMATIC ACID HALIDES FOR SYNTHESIZING POLYAMIDES | Pharmacia Corporation (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003018552-A2 | AROMATIC AND HETEROAROMATIC ACID HALIDES FOR SYNTHESIZING POLYAMIDES | PHARMACIA CORPORATION (US) | 2003-03-06 | — | — | WO | disclosed |