Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | TOP1 | P11387 | 2/20 | 0.36 |
| ▸ | HRAS | P01112 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889890 | 0.85 | TDP1 (0.41) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL7116896 | 0.81 | POLB (0.35) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL6900641 | 0.81 | TOP1 (0.40) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL14535121 | 0.79 | TOP1 (0.45) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL6527019 | 0.79 | POLB (0.34) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL4850168 | 0.77 | HRAS (0.49) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL20581230 | 0.74 | HRAS (0.42) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL14509989 | 0.73 | MEN1 (0.49) | KDM4EP2RY12KMT2ARAB9AMEN1 | |
| SCHEMBL3357113 | 0.73 | HSD17B10 (0.44) | ARPOLBMAPTKMT2ARAB9A | |
| SCHEMBL20581148 | 0.71 | P2RY12 (0.43) | ARTOP1HRASESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430028-A2 | AROMATIC AND HETEROAROMATIC ACID HALIDES FOR SYNTHESIZING POLYAMIDES | Pharmacia Corporation (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-1421056-A1 | (ALPHA)-HALOENAMINE REAGENTS | Pharmacia Corporation (US) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003020684-A1 | (ALPHA)-HALOENAMINE REAGENTS | PHARMACIA CORPORATION (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003018552-A2 | AROMATIC AND HETEROAROMATIC ACID HALIDES FOR SYNTHESIZING POLYAMIDES | PHARMACIA CORPORATION (US) | 2003-03-06 | — | — | WO | disclosed |