Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549230 | 0.90 | NPC1 (0.37) | POLBKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL549362 | 0.86 | POLB (0.54) | POLBKMT2AMAPTPKMKDM4E | |
| SCHEMBL549237 | 0.86 | POLB (0.50) | POLBKMT2AMAPTPKMKDM4E | |
| SCHEMBL5308733 | 0.85 | POLB (0.53) | POLBKMT2AMAPTPKMKDM4E | |
| SCHEMBL548445 | 0.83 | RAB9A (0.45) | POLBKMT2AMAPTKDM4ENPC1 | |
| SCHEMBL549231 | 0.79 | F2 (0.44) | POLBKMT2ATDP1RAB9A | |
| SCHEMBL549175 | 0.79 | POLB (0.35) | POLBKMT2AMAPTPKMKDM4E | |
| SCHEMBL548491 | 0.78 | F10 (0.43) | POLBMAPTPKMNPC1LMNA | |
| SCHEMBL549363 | 0.75 | MAPT (0.55) | POLBKMT2AMAPTPKMKDM4E | |
| SCHEMBL549238 | 0.75 | KMT2A (0.56) | POLBKMT2AMAPTPKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004002430-A2 | COMBINATIONS FOR THE TREATMENT OF FUNGAL INFECTIONS | COMBINATORX INCORPORATED (US) | 2004-01-08 | — | — | WO | disclosed |