SCHEMBL6901046

SCHEMBL6901046

CNc1cc(-c2ccc(OCC[C@@H]3CCN(c4ccccn4)C3)c(C(F)(F)F)c2)nc(C#N)c1N

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTSS P25774 20/20 0.56
CTSK P43235 13/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6899456 0.91 CTSS (0.55) CTSSCTSK
SCHEMBL6900955 0.87 CTSS (0.59) CTSSCTSK
SCHEMBL16457999 0.83 CTSS (0.78) CTSSCTSK
SCHEMBL13642267 0.83 CTSS (0.78) CTSSCTSK
SCHEMBL13642455 0.83 CTSS (0.78) CTSSCTSK
SCHEMBL6900455 0.83 CTSS (0.72) CTSSCTSK
Hydrochloric Acid SCHEMBL2146851 0.83 CTSS (0.77) CTSSCTSK
Hydrochloric Acid SCHEMBL2146854 0.83 CTSS (0.77) CTSSCTSK
Hydrochloric Acid SCHEMBL13584554 0.83 CTSS (0.77) CTSSCTSK
SCHEMBL6900980 0.83 CTSS (0.67) CTSSCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011086125-A1 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES N.V. ORGANON (NL) 2011-07-21 WO disclosed