SCHEMBL6901578

SCHEMBL6901578

CC=C(c1ccccc1)C(c1ccccc1)c1ccc(C=CC(=O)NS(=O)(=O)c2ccc(OC)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.51
HDAC4 P56524 2/20 0.51
BCHE P06276 1/20 0.48
CYP3A4 P08684 1/20 0.48
NFKB1 P19838 1/20 0.48
NFKB2 Q00653 1/20 0.48
RELA Q04206 1/20 0.48
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA9 Q16790 1/20 0.46
TAS1R3 Q7RTX0 1/20 0.46
TAS1R1 Q7RTX1 1/20 0.46
EGFR P00533 1/20 0.46
MMP1 P03956 1/20 0.46
MMP2 P08253 1/20 0.46
MMP9 P14780 1/20 0.46
HDAC3 O15379 2/20 0.45
HDAC2 Q92769 2/20 0.45
HDAC8 Q9BY41 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6898723 0.91 HDAC1 (0.48) HDAC1HDAC4EGFRHDAC3HDAC2
SCHEMBL6903710 0.90 HDAC4 (0.42) HDAC1HDAC4HDAC3HDAC2HDAC8
SCHEMBL6901609 0.89 HDAC1 (0.48) HDAC1HDAC4BCHECYP3A4MMP1
SCHEMBL6898018 0.89 HDAC3 (0.45) HDAC1HDAC4CYP3A4NFKB1NFKB2
SCHEMBL6900931 0.89 HDAC3 (0.45) HDAC1HDAC4HDAC3HDAC2HDAC8
SCHEMBL6901597 0.89 HDAC1 (0.48) HDAC1HDAC4CYP3A4EGFRMMP1
SCHEMBL6901651 0.88 FLT1 (0.51) HDAC1HDAC4CA12CA1CA2
SCHEMBL6898410 0.88 MEN1 (0.51) HDAC1HDAC4HDAC3HDAC2HDAC8
SCHEMBL6903905 0.86 HDAC3 (0.42) HDAC1HDAC4EGFRHDAC3HDAC2
SCHEMBL6902263 0.85 ALDH1A1 (0.47) HDAC1HDAC4CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1417169-A2 SELECTIVE ESTROGEN RECEPTOR MODULATORS Bristol-Myers Squibb Pharma Company (US) 2004-05-12 EP claimed
WO-2003016270-A2 SELECTIVE ESTROGEN RECEPTOR MODULATORS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2003-02-27 WO claimed
EP-1417169-A2 SELECTIVE ESTROGEN RECEPTOR MODULATORS Bristol-Myers Squibb Pharma Company (US) 2004-05-12 EP disclosed
WO-2003016270-A2 SELECTIVE ESTROGEN RECEPTOR MODULATORS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2003-02-27 WO disclosed