Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.48 |
| ▸ | TUBB | P07437 | 2/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345007 | 0.82 | KDM4E (0.61) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL14395085 | 0.80 | KDM4E (0.56) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL5219059 | 0.79 | KDM4E (0.50) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL2342953 | 0.77 | TUBB4A (0.63) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL2354376 | 0.76 | TUBB4A (0.59) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL5213578 | 0.76 | KDM4E (0.47) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL14395089 | 0.74 | HPGD (0.56) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL2348593 | 0.73 | KDM4E (0.60) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL2345966 | 0.73 | MAPT (0.60) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL2347244 | 0.73 | TUBB4A (0.60) | KDM4EHTR6TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833387-B1 | 3-substituted indoles; inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis; inflammatory diseases | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |
| EP-1173421-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000046199-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |