Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | MAN2B1 | O00754 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12240429 | 1.00 | PIK3CD (0.33) | PIK3CDHTR1DHTR1BMTORIRAK4 | |
| SCHEMBL9323835 | 0.85 | ALDH1A1 (0.41) | MAN2B1CYP1A2 | |
| SCHEMBL2037181 | 0.84 | PIK3CD (0.37) | PIK3CDHTR1DHTR1BIRAK4 | |
| SCHEMBL12051595 | 0.83 | — | — | |
| SCHEMBL12240416 | 0.83 | — | — | |
| SCHEMBL6902383 | 0.83 | — | — | |
| SCHEMBL22788135 | 0.82 | BRD4 (0.42) | PIK3CDHTR1DHTR1BIRAK4 | |
| SCHEMBL22788136 | 0.82 | HTR1D (0.33) | PIK3CDHTR1DHTR1BIRAK4 | |
| SCHEMBL10570165 | 0.79 | HTR1D (0.32) | PIK3CDHTR1DHTR1BIRAK4 | |
| SCHEMBL21657362 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865726-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | ARRAY BIOPHARMA INC. (US) | 2014-10-21 | — | — | US | disclosed |
| WO-2011029027-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-03-10 | — | — | WO | disclosed |