SCHEMBL6902158

SCHEMBL6902158

CC(Cn1cnc2c(Cl)nc(N)nc21)OCP(=O)(O)O

nearest known ligand 0.81

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 8/20 0.65
HDAC1 Q13547 2/20 0.48
HDAC6 Q9UBN7 2/20 0.48
HDAC4 P56524 1/20 0.48
CYP2D6 P10635 8/20 0.47
FDPS P14324 1/20 0.46
HSP90AA1 P07900 4/20 0.46
HSP90AB1 P08238 4/20 0.46
HPRT1 P00492 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6902140 1.00 CYP3A4 (0.65) CYP3A4HDAC1HDAC6HDAC4CYP2D6
SCHEMBL30515122 0.90 CYP3A4 (0.73) CYP3A4CYP2D6
SCHEMBL4312545 0.90 CYP3A4 (0.73) CYP3A4CYP2D6
SCHEMBL173030 0.90 CYP3A4 (0.73) CYP3A4CYP2D6
SCHEMBL1032335 0.90 CYP3A4 (0.73) CYP3A4CYP2D6
SCHEMBL7262136 0.88 CYP3A4 (0.64) CYP3A4CYP2D6HPRT1
SCHEMBL9177152 0.88 CYP3A4 (0.64) CYP3A4CYP2D6HSP90AA1HSP90AB1HPRT1
SCHEMBL9177212 0.88 CYP3A4 (0.64) CYP3A4CYP2D6HSP90AA1HSP90AB1HPRT1
SCHEMBL9176435 0.87 CYP3A4 (0.49) CYP3A4HDAC1HDAC6HDAC4HSP90AA1
SCHEMBL9177023 0.87 CYP3A4 (0.49) CYP3A4HDAC1HDAC6HDAC4HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3561272-B2 2004-09-02 JP claimed
EP-0654037-B1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1999-05-12 EP claimed
EP-0654037-A1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1995-05-24 EP claimed
WO-1994003467-A2 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1994-02-17 WO claimed
US-6479673-B1 Antiretroviral enantiomeric nucleotide analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2002-11-12 US disclosed