Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.46 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30515122 | 0.89 | CYP3A4 (0.73) | CYP3A4CYP2D6FAPCCNE1CDK2 | |
| SCHEMBL4312545 | 0.89 | CYP3A4 (0.73) | CYP3A4CYP2D6FAPCCNE1CDK2 | |
| SCHEMBL173030 | 0.89 | CYP3A4 (0.73) | CYP3A4CYP2D6FAPCCNE1CDK2 | |
| SCHEMBL1032335 | 0.89 | CYP3A4 (0.73) | CYP3A4CYP2D6FAPCCNE1CDK2 | |
| SCHEMBL6902140 | 0.88 | CYP3A4 (0.65) | CYP3A4CYP2D6HPRT1 | |
| SCHEMBL6902158 | 0.88 | CYP3A4 (0.65) | CYP3A4CYP2D6HPRT1 | |
| SCHEMBL9177152 | 0.87 | CYP3A4 (0.64) | CYP3A4CYP2D6FAPHPRT1CCNE1 | |
| SCHEMBL9177212 | 0.87 | CYP3A4 (0.64) | CYP3A4CYP2D6FAPHPRT1CCNE1 | |
| SCHEMBL6901145 | 0.85 | CYP3A4 (0.62) | CYP3A4CYP2D6FAPHPRT1 | |
| SCHEMBL6901159 | 0.85 | CYP3A4 (0.62) | CYP3A4CYP2D6FAPHPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653296-B1 | 2-phosphonomethoxypropyl derivatives of purine and pyrimidine bases | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2003-11-25 | — | — | US | disclosed |
| US-6479673-B1 | Antiretroviral enantiomeric nucleotide analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2002-11-12 | — | — | US | disclosed |
| US-6057305-A | Antiretroviral enantiomeric nucleotide analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2000-05-02 | — | — | US | disclosed |
| EP-0654037-B1 | ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 1999-05-12 | — | — | EP | disclosed |
| EP-0654037-A1 | ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003467-A2 | ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1994-02-17 | — | — | WO | disclosed |