Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34472829 | 0.82 | ALDH1A1 (0.58) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL6900242 | 0.82 | NR1H2 (0.49) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL1865727 | 0.81 | ALDH1A1 (0.62) | MAPTALDH1A1LMNAGPR119 | |
| SCHEMBL111070 | 0.81 | ALDH1A1 (0.72) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL392783 | 0.81 | ALDH1A1 (0.72) | MAPTALDH1A1LMNA | |
| SCHEMBL594206 | 0.81 | MAPT (1.00) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5724167 | 0.80 | ALDH1A1 (0.67) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL29945069 | 0.79 | ALDH1A1 (0.69) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL27030901 | 0.79 | MAPT (0.69) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL21279861 | 0.78 | MAPT (0.52) | MAPTALDH1A1LMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060321-A1 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-05-19 | — | — | WO | disclosed |