SCHEMBL6903105

SCHEMBL6903105

CC=C(c1ccccc1)C(c1ccccc1)c1ccc(C=CC(=O)NS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA9 Q16790 1/20 0.45
HDAC1 Q13547 5/20 0.44
HDAC8 Q9BY41 3/20 0.44
HDAC3 O15379 2/20 0.44
HDAC2 Q92769 2/20 0.44
HDAC10 Q969S8 2/20 0.44
HDAC11 Q96DB2 2/20 0.44
HDAC6 Q9UBN7 2/20 0.44
HDAC5 Q9UQL6 2/20 0.44
ADAM17 P78536 1/20 0.44
CTSL P07711 2/20 0.44
CTSS P25774 2/20 0.44
TRPA1 O75762 1/20 0.43
TRPM8 Q7Z2W7 1/20 0.43
EEF2K O00418 1/20 0.43
NOS3 P29474 1/20 0.43
NOS1 P29475 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6898723 0.90 HDAC1 (0.48) HDAC1HDAC8HDAC3HDAC2HDAC10
SCHEMBL6904409 0.90 HDAC1 (0.54) CA12CA1CA2CA9HDAC1
SCHEMBL6900931 0.88 HDAC3 (0.45) HDAC1HDAC8HDAC3HDAC2HDAC10
SCHEMBL6901597 0.88 HDAC1 (0.48) HDAC1HDAC8HDAC3HDAC2HDAC10
SCHEMBL6898018 0.88 HDAC3 (0.45) HDAC1HDAC8HDAC3HDAC2HDAC10
SCHEMBL6903905 0.87 HDAC3 (0.42) HDAC1HDAC8HDAC3HDAC2HDAC10
SCHEMBL6898410 0.87 MEN1 (0.51) HDAC1HDAC8HDAC3HDAC2HDAC10
SCHEMBL6901651 0.87 FLT1 (0.51) CA12CA1CA2CA9HDAC1
SCHEMBL6901578 0.85 HDAC1 (0.51) CA12CA1CA2CA9HDAC1
SCHEMBL6903710 0.85 HDAC4 (0.42) HDAC1HDAC8HDAC3HDAC2HDAC10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1417169-A2 SELECTIVE ESTROGEN RECEPTOR MODULATORS Bristol-Myers Squibb Pharma Company (US) 2004-05-12 EP claimed
WO-2003016270-A2 SELECTIVE ESTROGEN RECEPTOR MODULATORS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2003-02-27 WO claimed
EP-1417169-A2 SELECTIVE ESTROGEN RECEPTOR MODULATORS Bristol-Myers Squibb Pharma Company (US) 2004-05-12 EP disclosed
WO-2003016270-A2 SELECTIVE ESTROGEN RECEPTOR MODULATORS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2003-02-27 WO disclosed