Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL4663010 | 0.92 | CA1 (0.59) | CA1CA9TP53LMNAALDH1A1 | |
| Lactic Acid SCHEMBL17492265 | 0.92 | CA1 (0.59) | CA1CA9TP53LMNAALDH1A1 | |
| Lactic Acid SCHEMBL27514349 | 0.92 | CA1 (0.52) | CA1CA9TP53LMNAALDH1A1 | |
| Lactic Acid SCHEMBL28013571 | 0.86 | CA1 (0.52) | CA1CA9TP53LMNAALDH1A1 | |
| Lactic Acid SCHEMBL5570421 | 0.85 | CA1 (0.50) | CA1CA9TP53LMNAALDH1A1 | |
| Bicarbonate SCHEMBL980234 | 0.83 | CA1 (0.67) | CA1CA9TP53LMNAALDH1A1 | |
| Butyrolactone SCHEMBL16395005 | 0.82 | CA1 (0.54) | CA1CA9TP53LMNAALDH1A1 | |
| Lactic Acid SCHEMBL28067621 | 0.80 | OR51E2 (0.46) | CA1CA9TP53 | |
| Lactic Acid SCHEMBL14876478 | 0.79 | TP53 (0.48) | CA1CA9TP53TSHRPTGS1 | |
| Butyrolactone SCHEMBL9063485 | 0.79 | CA1 (0.61) | CA1CA9TP53LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716911-B2 | HIGH SOLID CONCENTRATION AND A HIGH VISCOSITY; KNEADING A POLYESTER AND AN AQUEOUS EMULSIFIER SOLUTION | SHOWA HIGHPOLYMER CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |