Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 6/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL136273 | 0.84 | — | — | |
| Bicarbonate SCHEMBL28578512 | 0.80 | CA1 (0.50) | CA1CA2CA9ALDH1A1FFAR3 | |
| Bicarbonate SCHEMBL28479909 | 0.80 | CA1 (0.50) | CA1CA2CA9ALDH1A1FFAR3 | |
| SCHEMBL6903777 | 0.79 | ALDH1A1 (0.35) | ALDH1A1FFAR3LCKFYNTSHR | |
| Bicarbonate SCHEMBL28781234 | 0.76 | ALDH1A1 (0.50) | CA1CA2CA9ALDH1A1FFAR3 | |
| Urea SCHEMBL4373666 | 0.76 | — | — | |
| Bicarbonate SCHEMBL28649909 | 0.76 | ALDH1A1 (0.50) | CA1CA2CA9ALDH1A1FFAR3 | |
| Bicarbonate SCHEMBL7192999 | 0.76 | — | — | |
| Bicarbonate SCHEMBL29206257 | 0.76 | ALDH1A1 (0.50) | CA1CA2CA9ALDH1A1FFAR3 | |
| Bicarbonate SCHEMBL28882374 | 0.76 | ALDH1A1 (0.50) | CA1CA2CA9ALDH1A1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6680394-B1 | OXIDATION OF VEGETABLE OILS USING OXYGEN, THEN PRESSURIZATION AND HEATING TO FORM BINDERS, USED AS LINOLEUM CEMENTS | DLW AKTIENGESELLSCHAFT (DE) | 2004-01-20 | — | — | US | disclosed |