Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | FADS1 | O60427 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654550 | 0.83 | CHRNA7 (0.43) | MAOBMAOAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL3652982 | 0.83 | CHRNA7 (0.43) | MAOBMAOAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL3652984 | 0.83 | CHRNA7 (0.43) | MAOBMAOAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL5281444 | 0.82 | IDH1 (0.43) | — | |
| SCHEMBL5286742 | 0.82 | IDH1 (0.43) | — | |
| SCHEMBL2615701 | 0.82 | IDH1 (0.43) | — | |
| SCHEMBL10308940 | 0.82 | MTOR (0.38) | MTOR | |
| SCHEMBL8168600 | 0.82 | MTOR (0.38) | MTOR | |
| SCHEMBL16181385 | 0.81 | CYP19A1 (0.45) | CYP19A1MAOBMAOAKDM4EHTT | |
| SCHEMBL10308932 | 0.80 | KMT2A (0.48) | CYP19A1MAOBMAOAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865726-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | ARRAY BIOPHARMA INC. (US) | 2014-10-21 | — | — | US | disclosed |
| WO-2011029027-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-03-10 | — | — | WO | disclosed |