Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | AR | P10275 | 6/20 | 0.48 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 5/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892914 | 1.00 | LMNA (0.53) | LMNAMAPTARSERPINA6ALDH1A1 | |
| SCHEMBL7028398 | 1.00 | LMNA (0.53) | LMNAMAPTARSERPINA6ALDH1A1 | |
| SCHEMBL8377744 | 0.91 | LMNA (0.54) | LMNAMAPTARSERPINA6ALDH1A1 | |
| SCHEMBL12672221 | 0.91 | LMNA (0.54) | LMNAMAPTARSERPINA6ALDH1A1 | |
| SCHEMBL13178781 | 0.91 | LMNA (0.54) | LMNAMAPTARSERPINA6ALDH1A1 | |
| SCHEMBL12639003 | 0.91 | MAPT (0.63) | LMNAMAPTARSERPINA6ALDH1A1 | |
| SCHEMBL7032081 | 0.91 | LMNA (0.54) | LMNAMAPTARSERPINA6ALDH1A1 | |
| SCHEMBL13139939 | 0.91 | MAPT (0.63) | LMNAMAPTARSERPINA6ALDH1A1 | |
| SCHEMBL24711298 | 0.91 | LMNA (0.53) | LMNAMAPTARSERPINA6ALDH1A1 | |
| SCHEMBL13139922 | 0.91 | LMNA (0.56) | LMNAMAPTARSERPINA6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0943328-B1 | Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia | ENDORECH INC (CA) | 2004-06-16 | — | — | EP | disclosed |
| EP-0595796-B1 | METHOD OF TREATMENT OF ANDROGEN-RELATED DISEASES | ENDORECH INC (CA) | 2003-01-15 | — | — | EP | disclosed |
| US-6423698-B1 | ADMINISTERING INHIBITOR OF 17-BETA-HYDROXYSTEROID DEHYDROGENASE AND AT LEAST ONE OF AN INHIBITOR OF AROMATASE AND INHIBITOR OF 5-ALPHA-REDUCTASE | ENDORECHERCHE, INC. (CA) | 2002-07-23 | — | — | US | disclosed |
| EP-0943328-A2 | Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia | ENDORECHERCHE INC. (CA) | 1999-09-22 | — | — | EP | disclosed |
| EP-0480950-B1 | COMBINATION THERAPY FOR PROPHYLAXIS AND/OR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | ENDORECHERCHE INC (CA) | 1999-03-24 | — | — | EP | disclosed |
| US-5840735-A | ESTROGEN | ENDORECHERCHE INC. (CA) | 1998-11-24 | — | — | US | disclosed |
| US-5817649-A | Combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia | ENDORECHERCHE, INC. (CA) | 1998-10-06 | — | — | US | disclosed |
| EP-0857487-A2 | Combinations for prophylaxsis and/or treatment of benign prostatic hyperplasia containing a 17 beta-hydroxy steroid dehydrogenase (17bHSD) inhibitor and at least one further active ingredient | ENDORECHERCHE INC. (CA) | 1998-08-12 | — | — | EP | disclosed |
| US-5686465-A | PROVIDE ANTIESTROGENIC EFFECTS; USEFUL IN TREATMENT OF BREAST CANCER | ENDORECHERCHE INC. (CA) | 1997-11-11 | — | — | US | disclosed |
| US-5686437-A | Estrogen nucleus derivatives for use in the inhibition of sex steroid activity | ENDORECHERCHE INC. (CA) | 1997-11-11 | — | — | US | disclosed |
| US-5372996-A | Method of treatment of androgen-related diseases | ENDORECHERCHE, INC. (CA) | 1994-12-13 | — | — | US | disclosed |
| EP-0615448-A1 | SEX STEROID ACTIVITY INHIBITORS | ENDORECHERCHE INC. (CA) | 1994-09-21 | — | — | EP | disclosed |
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| WO-1993010741-A2 | SEX STEROID ACTIVITY INHIBITORS | ENDORECHERCHE INC. (CA) | 1993-06-10 | — | — | WO | disclosed |
| US-5204337-A | Estrogen nucleus derivatives for use in inhibition of sex steroid activity | ENDORECHERCHE INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| WO-1991000733-A1 | METHOD OF TREATMENT OF ANDROGEN-RELATED DISEASES | ENDORECHERCHE INC. (CA) | 1991-01-24 | — | — | WO | disclosed |
| WO-1991000731-A1 | COMBINATION THERAPY FOR PROPHYLAXIS AND/OR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | ENDORECHERCHE INC. (CA) | 1991-01-24 | — | — | WO | disclosed |
| EP-0367576-A2 | Estrogen nucleus derivatives for use in the inhibition of sex steroid activity | ENDORECHERCHE INC. (CA) | 1990-05-09 | — | — | EP | disclosed |
| US-4659516-A | ANTIESTROGENS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-04-21 | — | — | US | disclosed |
| EP-0138504-A2 | Steroid derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-04-24 | — | — | EP | disclosed |