SCHEMBL6904546

SCHEMBL6904546

O=c1cccc2ccc3nccc3c2[nH]1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 4/20 0.46
CA9 Q16790 4/20 0.46
CYP3A4 P08684 1/20 0.41
KDM4E B2RXH2 2/20 0.40
MAPT P10636 2/20 0.40
KMT2A Q03164 2/20 0.40
ALDH1A1 P00352 1/20 0.40
DHFR P00374 1/20 0.40
GAA P10253 1/20 0.40
RAD52 P43351 1/20 0.40
BLM P54132 1/20 0.40
LMNA P02545 1/20 0.40
CYP19A1 P11511 3/20 0.38
HCAR1 Q9BXC0 2/20 0.38
ACVR1 Q04771 4/20 0.37
BMPR1B O00238 1/20 0.37
RAF1 P04049 1/20 0.37
BRAF P15056 1/20 0.37
BMPR1A P36894 1/20 0.37
ACVR1B P36896 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4464552 0.85 MAPT (0.50) CA12CA9CYP3A4KDM4EMAPT
SCHEMBL18839343 0.79 CYP19A1 (0.38) CYP3A4KDM4EMAPTKMT2AALDH1A1
SCHEMBL25348410 0.74 MAPT (0.46) CYP3A4KDM4EMAPTKMT2AALDH1A1
SCHEMBL146383 0.74 CYP3A4 (0.44) CYP3A4KDM4EMAPTKMT2AALDH1A1
SCHEMBL29152962 0.73 CYP19A1 (0.38) CYP3A4KDM4EMAPTKMT2AALDH1A1
Benzoquinone SCHEMBL27411699 0.73 CYP3A4 (0.38) CA12CA9CYP3A4KDM4EMAPT
SCHEMBL29586567 0.72 CYP3A4 (0.43) CYP3A4KDM4EMAPTKMT2AALDH1A1
SCHEMBL29190842 0.72 CYP3A4 (0.43) CYP3A4KDM4EMAPTKMT2AALDH1A1
Fluoride SCHEMBL28071548 0.72 CYP3A4 (0.43) CYP3A4KDM4EMAPTKMT2AALDH1A1
SCHEMBL31358268 0.72 CYP3A4 (0.43) CYP3A4KDM4EMAPTKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6806267-B1 ANTITUMOUR AGENTS; OVERCOMING CHRONIC MYELOID LEUKEMIA ASSOCIATED DRUG RESISTANCE; SUCH AS 4-ACETOXY-5-PHENYL-NAPHTO(2,3-B)PYRROLO(1,2-D)(1,4)OXAZEPINE THE UNIVERSITA'DI SIENA (IT) 2004-10-19 US disclosed
WO-1999056736-A2 APOPTOSIS-INDUCING COMPOUNDS THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) 1999-11-11 WO disclosed
US-4436662-A SEDATIVES, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1984-03-13 US disclosed