Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.36 |
| ▸ | POLQ | O75417 | 2/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10308878 | 0.82 | MTOR (0.41) | MTORMGLLGRIN1GRIN2BPOLQ | |
| SCHEMBL16181401 | 0.78 | MTOR (0.40) | MTORGRIN1GRIN2BPOLQIDH1 | |
| SCHEMBL16181417 | 0.77 | MTOR (0.37) | MTORIDH1 | |
| SCHEMBL6903482 | 0.75 | MTOR (0.42) | MTORIDH1 | |
| SCHEMBL16181420 | 0.74 | MTOR (0.38) | MTOR | |
| SCHEMBL6902761 | 0.73 | MTOR (0.44) | MTORGRIN1GRIN2BIDH1 | |
| SCHEMBL6902382 | 0.72 | MTOR (0.37) | MTORIDH1 | |
| SCHEMBL10308940 | 0.72 | MTOR (0.38) | MTOR | |
| SCHEMBL8168600 | 0.72 | MTOR (0.38) | MTOR | |
| SCHEMBL6902759 | 0.71 | MAPK1 (0.40) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865726-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | ARRAY BIOPHARMA INC. (US) | 2014-10-21 | — | — | US | disclosed |
| WO-2011029027-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-03-10 | — | — | WO | disclosed |