Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.42 |
| ▸ | GRM5 | P41594 | 6/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16181420 | 0.84 | MTOR (0.38) | MTORMAPTPDE10A | |
| SCHEMBL6902382 | 0.82 | MTOR (0.37) | MTORIDH1SMN1; SMN2PDE10A | |
| SCHEMBL10308842 | 0.82 | MTOR (0.39) | MTORGRM5IDH1 | |
| SCHEMBL6903019 | 0.82 | MTOR (0.40) | MTORIDH1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6902761 | 0.77 | MTOR (0.44) | MTORIDH1 | |
| SCHEMBL6903965 | 0.76 | CYP19A1 (0.39) | MTORLMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL10308934 | 0.76 | IDH1 (0.48) | MTORIDH1MAPT | |
| SCHEMBL6904739 | 0.75 | MTOR (0.43) | MTORIDH1 | |
| SCHEMBL6903480 | 0.73 | MTOR (0.42) | MTORIDH1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL16181384 | 0.72 | SRD5A1 (0.41) | MTORHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865726-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | ARRAY BIOPHARMA INC. (US) | 2014-10-21 | — | — | US | disclosed |
| WO-2011029027-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-03-10 | — | — | WO | disclosed |