Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 3/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961494 | 0.88 | BRAF (0.40) | BRAFUBE2MDCUN1D1KDRRIPK1 | |
| Hydrochloric Acid SCHEMBL5961417 | 0.87 | BRAF (0.40) | BRAFUBE2MDCUN1D1KDRRIPK1 | |
| SCHEMBL5961500 | 0.85 | GRM4 (0.38) | BRAFUBE2MDCUN1D1KDRRIPK1 | |
| SCHEMBL5961556 | 0.75 | CCR2 (0.45) | BRAFUBE2MDCUN1D1KDRCCR2 | |
| SCHEMBL5961552 | 0.74 | CCR2 (0.47) | BRAFKDRCCR2CCR5THRB | |
| SCHEMBL5961513 | 0.73 | CCR2 (0.46) | BRAFUBE2MDCUN1D1KDRCCR2 | |
| Hydrochloric Acid SCHEMBL5961470 | 0.73 | CCR2 (0.46) | BRAFUBE2MDCUN1D1KDRCCR2 | |
| SCHEMBL5961583 | 0.71 | CCR2 (0.48) | BRAFUBE2MDCUN1D1KDRGRM4 | |
| SCHEMBL5961482 | 0.71 | CCR2 (0.51) | KDRGRM4CDK8CCR2CCR5 | |
| Hydrochloric Acid SCHEMBL5961505 | 0.71 | CCR2 (0.47) | BRAFUBE2MDCUN1D1KDRGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077680-A1 | Antagonists of MCP-1 function and methods of use thereof | TELIK, INC. | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077680-A1 | Antagonists of MCP-1 function and methods of use thereof | CCR2, CCR1, CCL2 | BRAF 957/4885UBE2M 4709/4885DCUN1D1 1608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.