Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 14/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 14/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 14/20 | 0.71 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.44 |
| ▸ | OXTR | P30559 | 1/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651799 | 0.84 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6653998 | 0.84 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL1904637 | 0.84 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL1905352 | 0.83 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL27497515 | 0.83 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL1906421 | 0.82 | MAPK14 (0.87) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6905617 | 0.81 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL7642695 | 0.81 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11DHODH | |
| SCHEMBL6904778 | 0.81 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL1906478 | 0.80 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | claimed |