Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 14/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 14/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 14/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6905617 | 0.99 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL6905604 | 0.81 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL6653998 | 0.80 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL1904637 | 0.79 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6903356 | 0.79 | MAPK13 (0.51) | MAPK14MAPK13MAPK12MAPK11POLB | |
| SCHEMBL6904590 | 0.79 | MAPK13 (0.51) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL6905033 | 0.79 | MAPK13 (0.51) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL1905352 | 0.79 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL27497515 | 0.79 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL6824822 | 0.78 | MAPK13 (0.67) | MAPK14MAPK13MAPK12MAPK11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | claimed |