Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.68 |
| ▸ | PGR | P06401 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.68 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13659043 | 1.00 | NR3C1 (0.68) | NR3C1PGRCYP3A4LMNACYP1A2 | |
| SCHEMBL11036558 | 0.93 | NR3C1 (0.64) | NR3C1PGRCYP3A4LMNACYP1A2 | |
| SCHEMBL14794113 | 0.90 | NR3C1 (0.56) | NR3C1PGRCYP3A4LMNACYP1A2 | |
| SCHEMBL11076081 | 0.90 | NR3C1 (0.55) | NR3C1PGRCYP3A4LMNACYP1A2 | |
| SCHEMBL11581859 | 0.89 | NR3C1 (0.60) | NR3C1PGRCYP3A4LMNACYP1A2 | |
| SCHEMBL11580265 | 0.89 | NR3C1 (0.60) | NR3C1PGRCYP3A4LMNACYP1A2 | |
| SCHEMBL3982428 | 0.88 | NR3C1 (0.60) | NR3C1PGRCYP3A4LMNACYP1A2 | |
| SCHEMBL4214294 | 0.88 | NR3C1 (0.53) | NR3C1PGRCYP3A4LMNACYP1A2 | |
| SCHEMBL14794076 | 0.87 | NR3C1 (0.56) | NR3C1PGRCYP3A4LMNACYP1A2 | |
| SCHEMBL11586331 | 0.87 | NR3C1 (0.66) | NR3C1PGRCYP3A4LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448202-A1 | COMBINATION OF A PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA Pharma AG (DE) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003039552-A1 | COMBINATION OF PDE4 OR PDE3/4 INHIBITOR AND AN ANTI-RHEUMATIC DRUG | ALTANA PHARMA AG (DE) | 2003-05-15 | — | — | WO | disclosed |