Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDM6B | O15054 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | EIF4E | P06730 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30292662 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KDM4CKDM4ETDP1KDM6B | |
| SCHEMBL30292657 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KDM4CKDM4ETDP1KDM6B | |
| SCHEMBL2222831 | 0.90 | ALDH1A1 (0.50) | ALDH1A1KDM4CKDM4ETDP1KDM6B | |
| Hydrochloric Acid SCHEMBL7279409 | 0.89 | ALDH1A1 (0.49) | ALDH1A1KDM4CKDM4ETDP1KDM6B | |
| SCHEMBL30863845 | 0.87 | KDM4C (0.57) | ALDH1A1KDM4CKDM4ETDP1KDM6B | |
| SCHEMBL30705023 | 0.85 | MKNK1 (0.56) | ALDH1A1KDM4CKDM4ETDP1KDM6B | |
| SCHEMBL10364611 | 0.85 | MKNK1 (0.56) | ALDH1A1KDM4CKDM4ETDP1KDM6B | |
| SCHEMBL2556432 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4CKDM4ETDP1KDM6B | |
| SCHEMBL2558137 | 0.83 | MAPT (0.46) | ALDH1A1KDM4CKDM4ETDP1KDM6B | |
| SCHEMBL25306948 | 0.82 | SIRT3 (0.61) | TDP1MAPTSIRT3CDC7IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723723-B1 | PYRIDYL, PYRIMIDINYL OR PYRIDAZINE DERIVATIVES; ANTICOAGULANTS | ASTRAZENECA (SE) | 2004-04-20 | — | — | US | disclosed |