Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 11/20 | 0.59 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.59 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816809 | 0.89 | MAPK1 (0.53) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL6905886 | 0.89 | MAPK13 (0.58) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL6905858 | 0.89 | MAPK13 (0.54) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL5174760 | 0.89 | MAPK13 (0.63) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL6904625 | 0.88 | MAPK14 (0.75) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL6824811 | 0.88 | MAPK13 (0.65) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL6396535 | 0.86 | MAPK14 (0.78) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL6400247 | 0.86 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL6905610 | 0.84 | MAPK13 (0.64) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL27484493 | 0.84 | MAPK14 (0.63) | MAPK13MAPK12MAPK11MAPK14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | claimed |
| CN-1167667-C | Aminobenzophenone compounds useful as inhibitors of IL-1 beta and TNF-alpha | ������˹ҩƷ��˾ | 2004-09-22 | — | — | CN | claimed |
| CN-1371359-A | Aminobenzophenones as inhibitors IL-1 beta and TNF-alpha | LEO PHARM PROD LTD (DK) | 2002-09-25 | — | — | CN | claimed |
| CN-1167667-C | Aminobenzophenone compounds useful as inhibitors of IL-1 beta and TNF-alpha | ������˹ҩƷ��˾ | 2004-09-22 | — | — | CN | disclosed |