Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.75 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.75 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.75 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7646834 | 0.93 | MAPK14 (0.80) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL27484493 | 0.92 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6094761 | 0.89 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6094767 | 0.89 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6905240 | 0.89 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL1906604 | 0.89 | MAPK14 (0.81) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL1906530 | 0.89 | MAPK14 (0.81) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6651799 | 0.89 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6903370 | 0.88 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6906594 | 0.88 | MAPK13 (0.59) | MAPK14MAPK13MAPK12MAPK11TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | claimed |