Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 5/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.36 |
| ▸ | SRC | P12931 | 4/20 | 0.36 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690623 | 0.82 | RARG (0.41) | GSK3ARARGRXRAPPARGMEN1 | |
| SCHEMBL16106403 | 0.82 | GSK3A (0.43) | GSK3AMAPK14SRCSYKRARG | |
| SCHEMBL692574 | 0.82 | GSK3A (0.41) | GSK3AMAPK14SRCSYKRARG | |
| SCHEMBL689916 | 0.80 | ALDH1A1 (0.44) | GSK3AMAPK14SRCSYKMEN1 | |
| SCHEMBL690060 | 0.80 | MAPK14 (0.53) | MAPK14 | |
| SCHEMBL19050453 | 0.79 | MAPK14 (0.41) | MAPK14MEN1HTTKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL689965 | 0.78 | MAPK14 (0.52) | MAPK14 | |
| SCHEMBL690766 | 0.78 | GSK3A (0.36) | GSK3AMAPK14SRCSYKRARG | |
| SCHEMBL692947 | 0.78 | HTT (0.42) | GSK3AMAPK14SRCSYKMEN1 | |
| SCHEMBL15371211 | 0.78 | MEN1 (0.36) | MAPK14MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |