Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.70 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.70 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.56 |
| ▸ | CDK9 | P50750 | 12/20 | 0.51 |
| ▸ | CDK7 | P50613 | 4/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.51 |
| ▸ | CCNH | P51946 | 3/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6911670 | 0.88 | CDK2 (0.56) | CDK2CCNE2CCNE1HDAC3HDAC4 | |
| SCHEMBL4929170 | 0.82 | CDK2 (1.00) | CDK2CCNE2CCNE1HDAC3HDAC4 | |
| SCHEMBL6906730 | 0.81 | CDK2 (0.84) | CDK2CCNE2CCNE1HDAC3HDAC4 | |
| SCHEMBL6911527 | 0.80 | CDK2 (0.68) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL26399636 | 0.75 | CDK2 (0.85) | CDK2CCNE2CCNE1HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL26128863 | 0.74 | CDK2 (0.84) | CDK2CCNE2CCNE1HDAC3HDAC4 | |
| SCHEMBL14067130 | 0.73 | HDAC3 (0.89) | CDK2CCNE2CCNE1HDAC3HDAC4 | |
| SCHEMBL24758393 | 0.73 | CDK2 (0.83) | CDK2CCNE2CCNE1HDAC3HDAC4 | |
| SCHEMBL4996384 | 0.73 | CDK2 (0.79) | CDK2CCNE2CCNE1HDAC3HDAC4 | |
| SCHEMBL26129922 | 0.73 | CDK2 (0.81) | CDK2CCNE2CCNE1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429764-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2004-06-23 | — | — | EP | claimed |
| WO-2003020272-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-03-13 | — | — | WO | claimed |