Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.56 |
| ▸ | CDK9 | P50750 | 12/20 | 0.51 |
| ▸ | CDK7 | P50613 | 4/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.51 |
| ▸ | CCNH | P51946 | 3/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | CASK | O14936 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | ULK1 | O75385 | 1/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | PAK3 | O75914 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6906735 | 0.88 | CDK2 (0.70) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL6911527 | 0.83 | CDK2 (0.68) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL4928924 | 0.83 | CDK2 (0.81) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL6911667 | 0.81 | CDK2 (0.68) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL9950303 | 0.74 | HDAC3 (0.58) | CDK2CCNE2CCNE1CDK1CCNB1 | |
| SCHEMBL24510188 | 0.73 | CDK2 (0.50) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL3467070 | 0.72 | HDAC3 (0.56) | CDK2CCNE2CCNE1CDK1CCNB1 | |
| SCHEMBL24758127 | 0.72 | CDK2 (0.79) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL20905302 | 0.72 | CDK2 (1.00) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL24528750 | 0.71 | CDK2 (0.84) | CDK2CCNE2CCNE1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429764-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2004-06-23 | — | — | EP | claimed |
| WO-2003020272-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-03-13 | — | — | WO | claimed |