Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2272618 | 0.90 | JAK1 (0.47) | JAK1JAK2 | |
| SCHEMBL2275585 | 0.89 | JAK1 (0.37) | JAK1JAK2 | |
| SCHEMBL2272020 | 0.87 | JAK1 (0.41) | JAK1JAK2 | |
| SCHEMBL2275999 | 0.87 | KIT (0.39) | JAK1JAK2 | |
| SCHEMBL2273588 | 0.80 | PSEN1 (0.36) | — | |
| SCHEMBL2273026 | 0.79 | JAK2 (0.35) | JAK1JAK2 | |
| SCHEMBL2270828 | 0.79 | TAF1 (0.35) | — | |
| SCHEMBL17907539 | 0.77 | SMPD3 (0.34) | — | |
| SCHEMBL2273594 | 0.77 | PSEN1 (0.37) | — | |
| SCHEMBL2275498 | 0.73 | HRH4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486967-B2 | Heteroaryl substituted piperidines | HOFFMANN-LA ROCHE INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | HOFFMANN-LA ROCHE, INC. | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | APP, HPGDS, PSEN1 | JAK1 4402/4885JAK2 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.