Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL8380987 | 0.85 | HTR2A (0.38) | SIGMAR1HTR2AKDM4ELMNATP53 | |
| Dimethylamine SCHEMBL6908384 | 0.85 | KDM4E (0.41) | SIGMAR1HTR2AKDM4ELMNATP53 | |
| SCHEMBL814489 | 0.84 | HTR2A (0.41) | SIGMAR1HTR2AKDM4ELMNATP53 | |
| SCHEMBL16296388 | 0.84 | HTR2A (0.41) | SIGMAR1HTR2AKDM4ELMNATP53 | |
| SCHEMBL29758183 | 0.84 | HTR2A (0.41) | SIGMAR1HTR2AKDM4ELMNATP53 | |
| Methyl Alcohol SCHEMBL8383611 | 0.83 | HTR2A (0.38) | SIGMAR1HTR2AKDM4ELMNATP53 | |
| Chloromethane SCHEMBL8149410 | 0.83 | HTR2A (0.38) | SIGMAR1HTR2AKDM4ELMNATP53 | |
| Methylamine SCHEMBL27634217 | 0.83 | HTR2A (0.42) | SIGMAR1HTR2AKDM4ELMNATP53 | |
| Hydrochloric Acid SCHEMBL5709238 | 0.82 | HTR2A (0.40) | SIGMAR1HTR2AKDM4ELMNATP53 | |
| Hydrochloric Acid SCHEMBL7250686 | 0.82 | HTR2A (0.40) | SIGMAR1HTR2AKDM4ELMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839842-B1 | Film made from an Ethylene-alpha-olefin copolymer | MITSUBISHI CHEM CORP (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-6448356-B1 | NARROW MOLECULAR WEIGHT DISTRIBUTION; CONTROLLING DENSITY | MITSUBISHI CHEMICAL CORPORATION (JP) | 2002-09-10 | — | — | US | disclosed |
| US-20020035227-A1 | Ethylene-alpha-olefin copolymer | MITSUBISHI CHEMICAL CORPORATION (JP) | 2002-03-21 | — | — | US | disclosed |
| EP-0683180-B1 | Catalyst for polymerizing an olefin and method for polymerizing the olefin | MITSUBISHI CHEM CORP (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-5973084-A | HOMO OR COPOLYMERIZING AN ALPHA-OLEFIN IN PRESENCE OF A CATALYTIC SYSTEM CONTAINING METALLOCENE TYPE TRANSITIONAL METAL COMPOUND, AN ION EXCHANGED LAYERED COMPOUND OTHER THAN SILICATE AND AN INORGANIC ACID OR SALT TREATED SILICATE | MITSUBISHI CHEMICAL CORPORATION (JP) | 1999-10-26 | — | — | US | disclosed |
| US-5928982-A | METALLOCENE TRANSITION METAL COMPOUND, (1) AN ION-EXCHANGING LAYERED COMPOUND OTHER THAN A SILICATE OR (2) AN INORGANIC SILICATE PREPARED BY TREATING A STARTING ION-EXCHANGING LAYER COMPOUND OTHER THAN A SILICATE OR A STARTING SILICATE WITH A | MITSUBISHI CHEMICAL CORPORATION (JP) | 1999-07-27 | — | — | US | disclosed |
| EP-0839842-A2 | Ethylene-alpha-olefin copolymer | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-05-06 | — | — | EP | disclosed |
| EP-0683180-A2 | Catalyst for polymerizing an olefin and method for polymerizing the olefin | MITSUBISHI CHEMICAL CORPORATION (JP) | 1995-11-22 | — | — | EP | disclosed |