Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.35 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785557 | 1.00 | ALDH1A1 (0.38) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL6907348 | 1.00 | ALDH1A1 (0.38) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL5702772 | 0.78 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL15263374 | 0.76 | HPRT1 (0.41) | ALDH1A1HSD17B10TSHRTDP1HPRT1 | |
| SCHEMBL6670237 | 0.76 | CYP1A2 (0.41) | ALDH1A1HSD17B10TSHRTDP1CYP1A2 | |
| SCHEMBL6735412 | 0.76 | CYP1A2 (0.41) | ALDH1A1HSD17B10TSHRTDP1CYP1A2 | |
| SCHEMBL3343814 | 0.76 | CYP1A2 (0.41) | ALDH1A1HSD17B10TSHRTDP1CYP1A2 | |
| SCHEMBL3343813 | 0.76 | CYP1A2 (0.41) | ALDH1A1HSD17B10TSHRTDP1CYP1A2 | |
| SCHEMBL5859155 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL9245394 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794167-B2 | PROTEIN COMPLEX FOR USE IN THE BIOSYNTHESIS OF PREFERENTIAL COMPOUNDS | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2004-09-21 | — | — | US | disclosed |
| US-20030022335-A1 | Novel polypeptides and methods for their use | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2003-01-30 | — | — | US | disclosed |
| WO-2000037480-A1 | NOVEL NAPHTHALENE DIOXYGENASE AND METHODS FOR THEIR USE | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2000-06-29 | — | — | WO | disclosed |