Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.57 |
| ▸ | BCHE | P06276 | 9/20 | 0.52 |
| ▸ | BACE1 | P56817 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SCN4A | P35499 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1993388 | 1.00 | ACHE (0.57) | ACHEBCHEBACE1ALDH1A1SCN4A | |
| SCHEMBL20019719 | 1.00 | ACHE (0.57) | ACHEBCHEBACE1ALDH1A1SCN4A | |
| SCHEMBL14018259 | 1.00 | ACHE (0.57) | ACHEBCHEBACE1ALDH1A1SCN4A | |
| SCHEMBL20019720 | 1.00 | ACHE (0.57) | ACHEBCHEBACE1ALDH1A1SCN4A | |
| SCHEMBL12395260 | 1.00 | ACHE (0.57) | ACHEBCHEBACE1ALDH1A1SCN4A | |
| SCHEMBL352022 | 1.00 | ACHE (0.57) | ACHEBCHEBACE1ALDH1A1SCN4A | |
| Hydrochloric Acid SCHEMBL20597421 | 0.98 | ACHE (0.55) | ACHEBCHEBACE1ALDH1A1SCN4A | |
| Hydrochloric Acid SCHEMBL22500017 | 0.98 | ACHE (0.55) | ACHEBCHEBACE1ALDH1A1SCN4A | |
| Hydrochloric Acid SCHEMBL2148084 | 0.98 | ACHE (0.55) | ACHEBCHEBACE1ALDH1A1SCN4A | |
| Hydrochloric Acid SCHEMBL1373413 | 0.98 | ACHE (0.55) | ACHEBCHEBACE1ALDH1A1SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 253 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221572-A | Preparation method of cis-1-benzyl-4-methyl-3-methylamino-piperidine | 南京法恩化学有限公司 | 2024-06-21 | — | — | CN | claimed |
| CN-114835631-B | Preparation method of cis-1-benzyl-4-methyl-3-methylamino-piperidine dihydrochloride | 重庆恩联生物科技有限公司 | 2024-02-13 | — | — | CN | claimed |
| CN-114835631-A | Preparation method of cis-1-benzyl-4-methyl-3-methylamino-piperidine dihydrochloride | 重庆恩联生物科技有限公司 | 2022-08-02 | — | — | CN | claimed |
| CN-113735860-A | Synthesis method of tofacitinib citrate | 安徽鼎旺医药有限公司 | 2021-12-03 | — | — | CN | claimed |
| CN-111848496-B | Preparation method of tofacitinib intermediate amine and double hydrochloride thereof | 湖南华纳大药厂手性药物有限公司 | 2021-10-08 | — | — | CN | claimed |
| CN-111848496-A | Preparation method of tofacitinib intermediate amine and double hydrochloride thereof | 湖南华纳大药厂手性药物有限公司 | 2020-10-30 | — | — | CN | claimed |
| CN-108610279-B | Novel method for synthesizing cis-1-benzyl-3-methylamino-4-methyl-piperidine | 江苏苏利精细化工股份有限公司 | 2020-03-31 | — | — | CN | claimed |
| EP-3421455-B1 | IMPROVED PROCESS FOR THE PREPARATION OF CHIRAL 3-AMINO-PIPERIDINS, USEFUL INTERMEDIATES FOR THE PREPARATION OF TOFACITINIB | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2019-03-27 | — | — | EP | claimed |
| US-20190002407-A1 | PROCESS FOR THE PREPARATION OF CHIRAL 3-AMINO-PIPERIDINS, USEFUL INTERMEDIATES FOR THE PREPARATION OF TOFACITINIB | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2019-01-03 | — | — | US | claimed |
| EP-3421455-A1 | IMPROVED PROCESS FOR THE PREPARATION OF CHIRAL 3-AMINO-PIPERIDINS, USEFUL INTERMEDIATES FOR THE PREPARATION OF TOFACITINIB | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-01-02 | — | — | EP | claimed |
| US-20160102057-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | UNICHEM LABORATORIES LIMITED (IN) | 2016-04-14 | — | — | US | claimed |
| EP-2994454-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | UNICHEM LABORATORIES LIMITED (IN) | 2016-03-16 | — | — | EP | claimed |
| WO-2015087201-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | UNICHEM LABORATORIES LIMITED (IN) | 2015-06-18 | — | — | WO | claimed |
| US-12227478-B2 | Processes for preparing (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine or a salt thereof and processes for preparing tofacitinib using the same | YUHAN CORPORATION (KR) | 2025-02-18 | — | — | US | disclosed |
| US-20240279179-A1 | SYNTHESIS AND USE OF 1-BENZYL-4-METHYL-5-ALKOXY-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2024-08-22 | — | — | US | disclosed |
| CN-118221572-A | Preparation method of cis-1-benzyl-4-methyl-3-methylamino-piperidine | 南京法恩化学有限公司 | 2024-06-21 | — | — | CN | disclosed |
| WO-2002096909-A1 | OPTICAL RESOLUTION OF (1-BENZYL-4-METHYLPIPERIDIN-3-YL) -METHYLAMINE AND THE USE THEREOF FOR THE PREPARATION OF PYRROLO 2,3-PYRIMIDINE DERIVATIVES AS PROTEIN KINASES INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-12-05 | — | — | WO | disclosed |
| US-20020068746-A1 | Pyrrolo[2,3-d]pyrimidine compounds | PFIZER INC. | 2002-06-06 | — | — | US | disclosed |
| WO-2002000661-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS | PFIZER PRODUCTS INC. (US) | 2002-01-03 | — | — | WO | disclosed |
| US-20010053782-A1 | Immunosuppressants; organ transplant | BLUMENKOPF TODD A (US) | 2001-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240279179-A1 | SYNTHESIS AND USE OF 1-BENZYL-4-METHYL-5-ALKOXY-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVE | JAK1, JAK2, JAK3 | ACHE 4715/4885BCHE 3947/4885BACE1 4072/4885 |
| US-12227478-B2 | Processes for preparing (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine or a salt thereof and processes for preparing tofacitinib using the same | JAK3, JAK1, JAK2 | ACHE 4623/4885BCHE 4223/4885BACE1 4459/4885 |
| US-20160102057-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | KDM4D, KDM4A, KDM4C | ACHE 725/4885BCHE 869/4885BACE1 3256/4885 |
| US-20020068746-A1 | Pyrrolo[2,3-d]pyrimidine compounds | JAK1, CDK2, JAK3 | ACHE 4723/4885BCHE 4352/4885BACE1 3306/4885 |
| US-20190002407-A1 | PROCESS FOR THE PREPARATION OF CHIRAL 3-AMINO-PIPERIDINS, USEFUL INTERMEDIATES FOR THE PREPARATION OF TOFACITINIB | JAK3, JAK2, JAK1 | ACHE 4734/4885BCHE 4586/4885BACE1 4365/4885 |
| US-20010053782-A1 | Immunosuppressants; organ transplant | JAK1, JAK3, TPMT | ACHE 2231/4885BCHE 2944/4885BACE1 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.