Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.47 |
| ▸ | CETP | P11597 | 6/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6912365 | 0.86 | PPARG (0.46) | CETPFFAR1TSHRHSD17B10PTGES | |
| SCHEMBL10768533 | 0.85 | LTA4H (0.53) | LTA4HCETPFFAR1NPC1POLB | |
| SCHEMBL5531594 | 0.79 | LTA4H (0.48) | LTA4HCETPFFAR1NPC1POLB | |
| SCHEMBL3633492 | 0.78 | CETP (0.51) | LTA4HCETPFFAR1NPC1POLB | |
| SCHEMBL9861998 | 0.77 | LTA4H (0.49) | LTA4HCETPFFAR1NPC1POLB | |
| SCHEMBL9642238 | 0.77 | LTA4H (0.42) | LTA4HCETPFFAR1NPC1POLB | |
| SCHEMBL8735068 | 0.76 | LTA4H (0.47) | LTA4HCETPFFAR1NPC1POLB | |
| SCHEMBL10548514 | 0.76 | LTA4H (0.47) | LTA4HCETPFFAR1FFAR4PTGES | |
| SCHEMBL9029865 | 0.75 | LTA4H (0.49) | LTA4HCETPFFAR1NPC1POLB | |
| SCHEMBL9557910 | 0.75 | LTA4H (0.49) | LTA4HCETPFFAR1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490317-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082787-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-10-09 | — | — | WO | disclosed |