Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 17/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 16/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6909808 | 0.93 | HCRTR1 (0.41) | HCRTR2HCRTR1HSD11B1PTPN11 | |
| SCHEMBL6907825 | 0.93 | HCRTR1 (0.45) | HCRTR2HCRTR1 | |
| SCHEMBL6907794 | 0.92 | HCRTR1 (0.45) | HCRTR2HCRTR1 | |
| SCHEMBL6908569 | 0.86 | HCRTR1 (0.45) | HCRTR2HCRTR1 | |
| SCHEMBL6908966 | 0.85 | HCRTR1 (0.44) | HCRTR2HCRTR1PTPN11 | |
| SCHEMBL14973770 | 0.77 | HCRTR1 (0.50) | HCRTR2HCRTR1 | |
| SCHEMBL6908698 | 0.76 | HCRTR1 (0.45) | HCRTR2HCRTR1 | |
| SCHEMBL1586981 | 0.72 | HCRTR1 (0.61) | HCRTR2HCRTR1 | |
| SCHEMBL6908656 | 0.71 | HCRTR1 (0.45) | HCRTR2HCRTR1 | |
| SCHEMBL6908861 | 0.71 | HCRTR1 (0.68) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050202-A1 | FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-04-28 | — | — | WO | disclosed |