Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 13/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | MGLL | Q99685 | 3/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6909140 | 0.93 | HCRTR2 (0.42) | HCRTR1HCRTR2PTPN11HSD11B1 | |
| SCHEMBL6908966 | 0.92 | HCRTR1 (0.44) | HCRTR1HCRTR2PTPN11 | |
| SCHEMBL6907825 | 0.92 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL6907794 | 0.85 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL6908569 | 0.85 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL1586246 | 0.77 | HCRTR1 (0.49) | HCRTR1HCRTR2PTPN11 | |
| SCHEMBL6908142 | 0.77 | HCRTR1 (0.44) | HCRTR1HCRTR2PTPN11 | |
| SCHEMBL6909651 | 0.74 | HCRTR1 (0.44) | HCRTR1HCRTR2PTPN11 | |
| SCHEMBL1586440 | 0.73 | HCRTR1 (0.59) | HCRTR1HCRTR2 | |
| SCHEMBL1586097 | 0.72 | HCRTR1 (0.69) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050202-A1 | FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-04-28 | — | — | WO | disclosed |