Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 13/20 | 0.70 |
| ▸ | ABCC8 | Q09428 | 13/20 | 0.70 |
| ▸ | KCNJ11 | Q14654 | 13/20 | 0.70 |
| ▸ | KCNJ8 | Q15842 | 13/20 | 0.70 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6905395 | 0.96 | ABCC9 (0.77) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL6431754 | 0.94 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL6434255 | 0.92 | ABCC9 (0.77) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL6926386 | 0.85 | ABCC9 (0.85) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL29763183 | 0.83 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL3095468 | 0.83 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL4256078 | 0.83 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL5079077 | 0.81 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL7232595 | 0.80 | ABCC9 (0.54) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL6908767 | 0.80 | MEN1 (0.44) | ABCC9ABCC8KCNJ11KCNJ8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040097-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2004-04-14 | — | — | EP | claimed |
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | claimed |
| EP-1040097-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2004-04-14 | — | — | EP | disclosed |