SCHEMBL6909705

SCHEMBL6909705

CC(=O)Oc1cc(-c2nn(C)c(C(F)(F)F)c2Cl)c(F)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.35
MAPT P10636 3/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
CYP2C19 P33261 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
KDM4E B2RXH2 3/20 0.32
GLA P06280 2/20 0.32
GAA P10253 2/20 0.32
GFER P55789 1/20 0.32
ALDH1A1 P00352 2/20 0.32
HSD17B10 Q99714 2/20 0.32
USP2 O75604 1/20 0.32
HPGD P15428 1/20 0.32
HTR2A P28223 3/20 0.32
HTR2C P28335 2/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27321856 0.86 MAPT (0.31) MAPTSMN1; SMN2NPSR1CYP2C19MEN1
SCHEMBL9538983 0.85 SMN1; SMN2 (0.33) BACE1MAPTSMN1; SMN2NPSR1MEN1
SCHEMBL5398257 0.84 CYP1A2 (0.35) MAPTCYP2C19MEN1KMT2ACYP1A2
SCHEMBL6909703 0.83 PKM (0.44) CYP2C19KDM4EALDH1A1HSD17B10HPGD
SCHEMBL8569450 0.83 SMN1; SMN2 (0.33) MAPTSMN1; SMN2NPSR1MEN1KMT2A
SCHEMBL6911659 0.82 PTGDR2 (0.37) KDM4EALDH1A1HSD17B10HPGDHTR2A
SCHEMBL9696367 0.82 KDM4E (0.31) KDM4EGLAGAAGFERTNFSF11
SCHEMBL3725606 0.81 KDM4E (0.31) KDM4EGLAGAAGFER
SCHEMBL6911424 0.80 MEN1 (0.33) SMN1; SMN2CYP2C19MEN1KMT2ACYP1A2
SCHEMBL6912537 0.80 MEN1 (0.33) CYP2C19MEN1KMT2ACYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0553307-A1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO COMPANY (US) 1993-08-04 EP claimed
WO-1992006962-A1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO COMPANY (US) 1992-04-30 WO claimed
EP-0791571-B1 Benzoyl derivatives BAYER CROPSCIENCE AG (DE) 2004-06-16 EP disclosed
US-5496956-A BY ESTERIFICATION OF CARBOXY SUBSTITUTION WITH ALCOHOLS IN THE PRESENCE OF MINERAL ACID MONSANTO COMPANY (US) 1996-03-05 US disclosed
EP-0553307-A1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO COMPANY (US) 1993-08-04 EP disclosed
WO-1992006962-A1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO COMPANY (US) 1992-04-30 WO disclosed