Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330825 | 0.87 | CYP3A4 (0.49) | GAACYP3A4CYP2D6CYP1A2KDM4E | |
| SCHEMBL330972 | 0.87 | APOBEC3A (0.50) | GAACYP3A4CYP2D6CYP1A2KDM4E | |
| SCHEMBL330886 | 0.84 | LMNA (0.54) | GAACYP3A4CYP2D6CYP1A2KDM4E | |
| SCHEMBL10418852 | 0.84 | GAA (0.52) | GAACYP3A4CYP2D6CYP1A2KDM4E | |
| Benzene SCHEMBL29261851 | 0.83 | GAA (0.56) | GAACYP3A4CYP2D6CYP1A2KDM4E | |
| SCHEMBL11581865 | 0.83 | GAA (0.62) | GAACYP3A4CYP2D6CYP1A2KDM4E | |
| SCHEMBL6910997 | 0.83 | SMN1; SMN2 (0.54) | GAACYP3A4CYP2D6CYP1A2KDM4E | |
| Biphenyl SCHEMBL23364905 | 0.80 | CA12 (0.49) | GAACYP3A4CYP2D6CYP1A2KDM4E | |
| Toluene SCHEMBL27765033 | 0.79 | LMNA (0.50) | GAACYP3A4CYP2D6CYP1A2KDM4E | |
| Toluene SCHEMBL2311942 | 0.79 | LMNA (0.50) | GAACYP3A4CYP2D6CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736574-B1 | Thermoplastic resin composition comprising carbonate and acrylic resin | GEN ELECTRIC (US) | 2004-06-02 | — | — | EP | disclosed |
| US-6103827-A | A TRANSPARENT THERMOPLASTIC RESIN BLENDS | GENERAL ELECTRIC COMPANY (US) | 2000-08-15 | — | — | US | disclosed |
| US-5883194-A | RADIATION TRANSPARENT THERMOPLASTIC RESINS OF CARBONATE AND ESTER BLENDS WITH ACRYLATE RESINS AND CATALYSTS | GENERAL ELECTRIC COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0736574-A2 | Thermoplastic resin composition comprising carbonate and acrylic resin | GENERAL ELECTRIC COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |