Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCND2 | P30279 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067521 | 0.90 | RORC (0.36) | BRD4RORCMAPK8CDK4CCND1 | |
| SCHEMBL1065266 | 0.83 | MAPK14 (0.39) | RORCGRIN1GRIN2BMAPK8HMGCR | |
| SCHEMBL1059261 | 0.83 | CDK5 (0.39) | RORCGRIN1GRIN2BMAPK8 | |
| SCHEMBL1059149 | 0.81 | BRD4 (0.36) | BRD4RORCGRIN1GRIN2BHMGCR | |
| SCHEMBL1063029 | 0.78 | HSP90AB1 (0.46) | RORCHMGCRMAPK13MAPK12MAPK11 | |
| SCHEMBL1063010 | 0.78 | HMGCR (0.37) | RORCHMGCRMAPK13MAPK12MAPK11 | |
| SCHEMBL1061554 | 0.77 | CCNT1 (0.38) | GRIN1GRIN2BCDK4CCND1CCND2 | |
| SCHEMBL12122428 | 0.76 | CDK4 (0.34) | BRD4RORCGRIN1GRIN2BCDK4 | |
| SCHEMBL1065461 | 0.76 | CDK4 (0.34) | BRD4RORCGRIN1GRIN2BCDK4 | |
| SCHEMBL1064579 | 0.73 | CDK4 (0.42) | MAPK8CDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116697-A1 | Novel compounds | GLAXOSMITHKLINE LLC | 2004-06-17 | — | — | US | claimed |