Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 6/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1194120 | 1.00 | AHR (0.44) | AHRCYP1A2MAOBFBP1HSD17B10 | |
| SCHEMBL1194958 | 0.92 | AHR (0.38) | AHRCYP1A2MAOBFBP1LMNA | |
| SCHEMBL1194057 | 0.92 | MAOB (0.50) | AHRCYP1A2MAOBHSD17B10CXCL12 | |
| SCHEMBL7736953 | 0.92 | MAOB (0.43) | AHRCYP1A2MAOBNFE2L2PTGS2 | |
| SCHEMBL3668286 | 0.92 | MAOB (0.43) | AHRCYP1A2MAOBNFE2L2PTGS2 | |
| SCHEMBL1194536 | 0.92 | AHR (0.38) | AHRCYP1A2MAOBFBP1LMNA | |
| SCHEMBL5872205 | 0.92 | AHR (0.38) | AHRCYP1A2MAOBFBP1HSD17B10 | |
| SCHEMBL1194783 | 0.92 | MAOB (0.43) | AHRCYP1A2MAOBNFE2L2PTGS2 | |
| SCHEMBL5871754 | 0.92 | AHR (0.38) | AHRCYP1A2MAOBFBP1HSD17B10 | |
| SCHEMBL1194099 | 0.92 | MAOB (0.43) | AHRCYP1A2MAOBNFE2L2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767926-B1 | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2004-07-27 | — | — | US | disclosed |
| US-6656973-B2 | Anticancer chemotherapy, and cytoprotective agents administered before, during or after chemotherapy to protect the normal cells of the patient | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-02 | — | — | US | disclosed |