Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1194783 | 1.00 | MAOB (0.43) | MAOBGPR183PTGES2ALDH1A1AHR | |
| SCHEMBL3668286 | 1.00 | MAOB (0.43) | MAOBGPR183PTGES2ALDH1A1AHR | |
| SCHEMBL1194099 | 1.00 | MAOB (0.43) | MAOBGPR183PTGES2ALDH1A1AHR | |
| SCHEMBL15673888 | 0.92 | TNFRSF1A (0.42) | TNFRSF1APTGS2HSD11B1NFE2L2 | |
| SCHEMBL6911087 | 0.92 | AHR (0.44) | MAOBAHRPTGS2CYP1A2NFE2L2 | |
| SCHEMBL1194120 | 0.92 | AHR (0.44) | MAOBAHRPTGS2CYP1A2NFE2L2 | |
| SCHEMBL1195539 | 0.85 | PTGS2 (0.41) | MAOBAHRPTGS2CYP1A2NFE2L2 | |
| SCHEMBL1194057 | 0.84 | MAOB (0.50) | MAOBALDH1A1AHRMAPTPTGS2 | |
| SCHEMBL1194100 | 0.84 | MAPT (0.40) | GPR183PTGES2ALDH1A1NPC1MAPT | |
| SCHEMBL5872258 | 0.84 | TNFRSF1A (0.37) | GPR183TNFRSF1APTGS2HSD11B1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414034-B1 | ANTICANCER AGENTS | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2002-07-02 | — | — | US | claimed |
| CN-102821605-B | Improved stable aqueous formulations of -4-carboxystyryl-4-chlorobenzyl sulfone | ONCONOVA THERAPEUTICS, INC. (US) | 2015-11-25 | — | — | CN | disclosed |
| CN-104320971-A | Compositions and methods for prevention and treatment of wounds | ONCONOVA THERAPEUTICS INC | 2015-01-28 | — | — | CN | disclosed |