Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6906857 | 0.91 | MAPK13 (0.59) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6904989 | 0.91 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14RAB9A | |
| SCHEMBL6905240 | 0.90 | MAPK14 (0.68) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6905858 | 0.87 | MAPK13 (0.54) | MAPK13MAPK12MAPK11MAPK14RAB9A | |
| SCHEMBL6912992 | 0.87 | MAPK14 (0.58) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6906823 | 0.86 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6910297 | 0.86 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6909999 | 0.85 | MAPK14 (0.54) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL1906099 | 0.84 | MAPK13 (0.64) | MAPK13MAPK12MAPK11MAPK14RAB9A | |
| SCHEMBL2199221 | 0.84 | MAPK13 (0.47) | MAPK13MAPK12MAPK11MAPK14RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202957-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | claimed |
| US-6555710-B1 | Derivatives of 2,2,2-trifluoro-N-2-(benzoylphenylaminophenyl acetamide; antiinflammatory agents, suppression of interleukin (IL)-beta and tumor necrosis factor (TNF)-alpha; antiarthritic, anticholinergic agents; asthma; antiallergens | LEO PHARMACEUTICAL PRODUCTS LTD A/S LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) | 2003-04-29 | — | — | US | claimed |
| EP-1202957-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |
| US-6555710-B1 | Derivatives of 2,2,2-trifluoro-N-2-(benzoylphenylaminophenyl acetamide; antiinflammatory agents, suppression of interleukin (IL)-beta and tumor necrosis factor (TNF)-alpha; antiarthritic, anticholinergic agents; asthma; antiallergens | LEO PHARMACEUTICAL PRODUCTS LTD A/S LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) | 2003-04-29 | — | — | US | disclosed |