Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6912992 | 0.93 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL6905240 | 0.89 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL6903370 | 0.89 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL7647816 | 0.88 | MAPK13 (0.62) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL6904989 | 0.86 | MAPK13 (0.53) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL6911491 | 0.85 | MAPK13 (0.55) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL6905858 | 0.85 | MAPK13 (0.54) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL6906857 | 0.85 | MAPK13 (0.59) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL6824985 | 0.84 | MAPK13 (0.65) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL1906733 | 0.84 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202957-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |
| US-6555710-B1 | Derivatives of 2,2,2-trifluoro-N-2-(benzoylphenylaminophenyl acetamide; antiinflammatory agents, suppression of interleukin (IL)-beta and tumor necrosis factor (TNF)-alpha; antiarthritic, anticholinergic agents; asthma; antiallergens | LEO PHARMACEUTICAL PRODUCTS LTD A/S LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) | 2003-04-29 | — | — | US | disclosed |